Myofascial pain syndrome (MPS) is one of the most prevalent and significant health problems which causes diminished function and impaired quality of life. Myofascial pains are caused by myofascial trigger points which are characterized by discrete hyper contracted and sensitive foci within muscles and/or connective tissues. Clinical manifestations of these trigger points in the head and Neck region present as headache, Neck pain and temporomandibular dysfunction.MPS treatment is challenging, multidisciplinary, and still lacks a clear remedy. Different treatment options include physical therapy, medications, trigger point injection, acupuncture, chiropractic management, transcutaneous electrical nerve stimulation, and laser therapy. Laser is an effective modality in treating many acute and chronic musculoskeletal syndromes, it improves local microcirculation, oxygen supply, removes waste products, and increases mediators of pain inhibition. The advantages of laser, like, non-invasiveness, ease, short-term applications and fewer side effects make it favorite among clinicians.Numerous researches have been conducted to evaluate the efficacy of laser therapy for treatment of MPS. Different laser wavelengths, intensities, densities, dosages, and treatment intervals have been used in various animal and human studies. Laser therapy seems to be effective in pain relief, improvement of function and quality of life in patients with MPS and could be used as one of the treatment modalities.